Commissioned in 1206 by the Anatolian Seljuk Sultan Ghiyath al-Din Kaykhusraw I in accordance with the wishes of his sister, Gevher Nesibe Sultan, the Gevher Nesibe Hospital (Darüşşifa) and Gıyasiye Medical School in Kayseri are widely regarded as one of the world's earliest integrated medical complexes combining medical education with patient care.
The complex consisted of two interconnected sections: a medical school, where students received theoretical instruction, and a hospital, where aspiring physicians gained practical experience under the supervision of experienced practitioners. This integrated model represents one of the earliest known examples of combining medical education with clinical practice within a single institution.
Beyond the treatment of physical illness, the complex also reflected the holistic philosophy of healthcare that characterised its time. Its courtyards, water features and carefully planned architectural layout created a restorative environment intended to support patients' wellbeing, making Gevher Nesibe one of Anatolia's most significant medical heritage sites.